منابع مشابه
Cysteine proteinases and the pathogenesis of amebiasis.
Amebiasis is a major cause of morbidity and mortality throughout the tropical world. Entamoeba histolytica is now recognized as a separate species from the morphologically identical E. dispar, which cannot invade. Cysteine proteinases are a key virulence factor of E. histolytica and play a role in intestinal invasion by degrading the extracellular matrix and circumventing the host immune respon...
متن کاملLabelling of cysteine proteinases in purified lysosomes.
NADH could not be freeze-stored at -25°C in 50 mMsodium phosphate buffer (pH range 6-8 20°C) without serious loss of the nucleotide; however, no losses were seen upon freeze storage in 50 mM-Hepes buffer (pH range 7-8, 20°C). The rate of NADH degradation was greater (approx. 2-fold) in 50 mMthan in 5 mM-sodium phosphate buffer, although NADH values at both buffer concentrations were similar (5%...
متن کاملMultifunctional role of plant cysteine proteinases.
Cysteine proteinases also referred to as thiol proteases play an essential role in plant growth and development but also in senescence and programmed cell death, in accumulation of storage proteins such as in seeds, but also in storage protein mobilization. Thus, they participate in both anabolic and catabolic processes. In addition, they are involved in signalling pathways and in the response ...
متن کاملThe synthesis of peptidylfluoromethanes and their properties as inhibitors of serine proteinases and cysteine proteinases.
A synthesis of peptidylfluoromethanes is described that utilizes the conversion of phthaloyl amino acids into their fluoromethane derivatives. These can be deblocked and elongated. The inactivation of chymotrypsin by Cbz-Phe-CH2F (benzyloxycarbonylphenylalanylfluoromethane) was found to be considerably slower than that of the analogous chloromethane. The fluoromethane analogue inactivates chymo...
متن کاملHomology within the N-terminal extension of cysteine proteinases.
It is now well established that the cysteine proteinases of plants (e.g. papain, actinidin, bromelain) and animals (e.g. cathepsins B, H and L) are homologous (see Takio et al., 1983) and almost certainly evolved from a common ancestral protein. For all but one of the cysteine proteinases sequenced to date the N-terminal residues can be exactly aligned with one another at a distance of 25-29 re...
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ژورنال
عنوان ژورنال: Perspectives in Drug Discovery and Design
سال: 1996
ISSN: 0928-2866,1573-9023
DOI: 10.1007/bf02174046